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The main pathophysiological mechanisms underlying this syndrome include obesity, insulin resistance and hyperinsulinemia

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While the precise mechanisms linking copper and ferroptosis are still being studied, autophagy plays a multifaceted role in regulating metal-dependent cell death [152]

GHRH and its analogues (including sermorelin) stimulate the pituitary to release GH in humans, mimicking physiologic hormone rhythms and supporting the GH-IGF-1 axis without the supraphysiologic exposure of direct growth hormone injections

The DTX-NLCs showed high cellular internalisation in GBM cells as well as low IC50 [110]