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10.1111/j.1572-0241.1999.00790 Am J Gastroenterol

One of those ions is crucial for the operation of the enzyme: It is located at the catalytic site and holds the hydroxyl group of the alcohol in place

37,38 Both CCS and SOD1 are localized in both the cytoplasm and mitochondrial intermembrane space (IMS), where they detoxify mitochondria-derived superoxides