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Treatment with Actovegin improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activation

Yes, when used topically and from reputable brands

doi: 10.1128/MCB.23.23.8786-8794.2003 223 PajaresMJimenez-MorenoNGarcia-YagueAJEscollMde CeballosMLVan LeuvenFet al

Finally, as ECM changes are known to accompany a plethora of brain diseases, these findings should also prove relevant for clinical research in the future