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[315] Comment: A few commenters recommended stratification by ED volume, with a commenter suggesting stratifying ED volume as small, medium, or large, to enable meaningful comparisons across hospitals with varying patient volume and resource levels

Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects

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On top of that, low B12 contributes to high homocysteine levels

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Instead, it acts as an intracellular signaling peptide, engaging the AMPK pathway and influencing nuclear gene expression via a mitochondrial-nuclear retrograde signaling mechanism