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These medications work primarily through central appetite suppression, delayed gastric emptying, and enhanced satiety signaling

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Importantly, genetic predisposition is not a guarantee of medication response

In animal models of metabolic diseases, JBSNF-000028 (Ruf et al., 2022) and JBSNF-000088 (Kannt et al., 2018) were identified to inhibit human and mouse NNMT activity