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It has been extensively studied for its role in sleep regulation, neuroendocrine balance, and stress adaptation

Fang EF, Hou Y, Lautrup S, et al

Chem Rev 121:1408814188

[PMC free article: PMC2676998] [PubMed: 19211817] 627

Although this may offer systemic recovery and healing benefits, it introduces complexity in predicting responsesespecially in polypharmacy and comorbidity contexts

Therefore, there is an urgent need for large-scale, methodologically rigorous epidemiological studies to elucidate the potential role of methylation alterations in the development of various cancers and their impact on early detection in clinical samples such as blood, urine, sputum, feces, and tissues