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Age spots are deeper and may require longer treatment periods with stronger ingredients like kojic acid

doi: 10.1080/10715762.2023.2165918

24 ChenJ.WangL.WuC.HuQ.GuC.YanF.et al (2014)

This is because some of the intermediates that are formed are even more toxic than the original arsenic.[ref] The enzyme called Arsenite methyltransferase (AS3MT) helps add the methyl group to arsenic