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The inflammation-fibrosis-cancer cascade is not an inevitable pathway, but it does create a favorable environment for tumor development (Feng et al., 2025)

in a rat model of diabetic neuropathy

[Abstract]2024 Feb 12;25(2):792-808

Franceschi C, et al

The consequent derailment of the cellular behavior can thus lead towards apoptosis (a natural damage-limiting self-digestion of critically damaged cells, [85]), necrosis (an auto-sustaining, propagating tissue damage) and towards neoplastic transformation (an uncontrolled, invasive cellular growth)

Inhibition of IFN- signaling by using the IFN- monoclonal antibody (XMG1.2) in non-obese diabetic (NOD) mice can induce glutathione (GSH) and glutathione peroxidase 4 (GPX4), and relieve the SGEC ferroptosis and progression of SS (33)