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Cognitive function in obese individuals improves substantially with weight loss alone, but the direct central GLP-1R effects may contribute additional benefit beyond what weight reduction alone would predict

In the April 21, 2016 IFC (81 FR 23428 through 23438), referenced earlier in section III.G.1.a

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Potential Benefits of Cinnamon: Improved insulin sensitivity Reduced fasting glucose levels Antioxidant properties In summary, chromium , berberine , and cinnamon could help manage blood sugar and nerve health in neuropathy