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Circadian Rhythm Regulation: NAD+ biosynthesis via NAMPT is regulated by the CLOCK/BMAL1 circadian transcription complex, creating a circadian oscillation of NAD+ that drives rhythmic sirtuin activity across tissues linking NAD+ availability directly to circadian health and metabolic timing

Emerging research indicates a strong link between ferroptosis and the occurrence and progression of these musculoskeletal diseases, suggesting that targeting ferroptosis could offer a novel therapeutic approach for these diseases (Fig

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Gut microbe-modulating drugs, such as prebiotics, probiotics, and specific antibiotics, may positively affect MASLD and MASH by altering gut microbial composition

(Cytoprotective action is the action of protecting body cells from harmful influences)