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Key physiological effects include: Stimulates lipolysis the breakdown of stored triglycerides into free fatty acids

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2026 Mar 12;391(6790):1130-1137

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

Exendin-4 (exenatide), for example, shows greater beta-arrestin recruitment relative to cAMP signaling compared to native GLP-1, while semaglutide shows relatively balanced signaling

For a 31-amino-acid peptide like semaglutide, this requires approximately 31 coupling cycles, each involving activation of the incoming amino acid, coupling, deprotection, and washing steps