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The activation of microglia is regulated by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), which can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (Li and Wu, 2021)

Curcumin enhances the activity of intrinsic antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), while decreasing levels of malondialdehyde (MDA), a biomarker of lipid peroxidation

Notably, the ratio of apoptotic cells in the TLR2 pep-orid-liposome group was significantly and positively associated with the expression level of TLR2 according to statistical results

doi: 10.1016/j.cmet.2020.07.001 18 WeinbergSESingerBDSteinertEMMartinezCAMehtaMMMartinez-ReyesIet al

For skin-specific concerns, it is best to consult a healthcare provider or dermatologist to determine the appropriate treatment

doi: 10.3390/ijms23010280 184 MatthayM