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Disruption of the balance between these two factors is a determining factor in the onset of ferroptosis

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Accordingly, the bottom line in an acetaminophen overdose is that when the amount of NAPQI is too much for the available glutathione to detoxify, liver damage occurs

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B., Makes, W

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Bringing the concentration of free cysteine up to roughly match that shown above for free glycine kills off 70 percent of the cells (3)

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However, the mechanism underlying how glutamine uptake and metabolism to GSH occur in CRPC and their effects on ferroptosis are unclear

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