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You risk introducing bacteria and other pathogens from the air, which can then multiply inside the syringe - and the longer it is before you use it, the more they can multiply, potentially doubling in number every 20 minutes or so

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Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection

Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, Pediatric Acute Liver Failure Study Group (2013) Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial