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Analgesic and neuroprotective effects of Baimai Ointment on diabetic peripheral neuropathy

In addition to insulin resistance and hyperinsulinemia, NAFLD and CVD cluster with other common risk factors, including hypertension, hyperlipidemia, T2DM, obesity and inflammation (8)

By forming nonreactive molecules, Glutathione neutralizes hydrogen peroxide as well as oxygenated radicals that have disruptive effects on lipids, proteins, enzymes, and cellular DNA.

Furthermore, increased functional urease activity (urease B) and the production of ammonia disrupt the cellular cytoskeleton-mediated tight junctions by regulating the phosphorylation of myosin light chain (MLC) and endocytosis of the tight junction protein occluding, leading to enlarged intercellular spaces (Wroblewski et al., 2009)

It selectively reduces abnormal direct cell-cell interactions and changes the cargo of CD4 T cell-derived EVs

However, reports that relate antibody titres to disease progression involve relatively few patients 86,87,88 , and are confounded by the higher levels of antigen seen in severe infections that are predicted to drive a stronger immune response or a heightened innate inflammatory response