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Neuropharmacology 59, 121127

Phase 1 (Weeks 1 to 2): 0.25 mg subcutaneous injection once daily, morning on empty stomach Phase 2 (Weeks 3 to 6): Maintain 0.25 mg or increase to 0.5 mg based on response and tolerance Phase 3 (Weeks 7 to 8): Continue or begin taper depending on symptom improvement Maintenance: Consider cycling 4 weeks on, 2 weeks off for long-term management Oral dosing requires higher amounts to compensate for bioavailability differences

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Discovery and resupply of pharmacologically active plant-derived natural products: a review

It inhibits cyclooxygenase enzymes in central nervous system

Upregulation of p16 leads to the hypophosphorylation of the pRb protein and induction of senescence 11,40