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The potential benefits of therapies such as inhaled corticosteroids (ICS) [44,45,46] and anti-IL-5/anti-IL-5 receptor biologics [47] in mitigating exacerbations emphasize their importance for personalized treatment, pending further evaluation

Its mechanisms include regulating Nrf2 transcriptional levels, upregulating the expression of SOD, GSH, GPX4, FPN1, and SLC7A11, downregulating MDA, ACSL4, and ROS levels, effectively reducing abnormal iron accumulation in the brain, and ultimately decreasing A deposition

Presynaptic effects on transmitter release appear particularly important, and some molecular targets are known, eg, SV 2 A (see Figure 242 )

Factors to consider include those in the list below

The Blink TM NutriTears clinical studies enrolled patients with all types of clinically diagnosed dry eye disease

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