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Screening of 289 patients with coronary artery disease and 255 control subjects revealed 77 individuals with the G-50T SNP (17.3% of CAD patients, 10.6% of control subjects

The observed protective effect coincided with alterations in the expression of genes associated with oxidative balance (Noxa1, Gpx1, Ccs, and Sod1) and inflammation (Mpo, Ncf, Il1b, and Il4)