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Journal of Pharmaceutical and Biomedical Analysis 204:114255

DIPEA (1.08 mL, 6.20 mmol) was slowly added into the mixture

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Research has characterised whether the two distinct angiogenic mechanisms , VEGF/NO-dependent endothelial activation and PI3K/Akt-dependent endothelial migration , produce additive or synergistic new vessel formation in ischaemia and wound healing models, contributing to understanding of the mechanistic complementarity of the two angiogenic pathways