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Dysregulated lipid metabolism also promotes aberrant synthesis of pro-inflammatory lipid mediators such as prostaglandins and leukotrienes, thereby sustaining chronic neuroinflammatory states (Johnson and Stolzing, 2019

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Following lymphodepleting chemotherapy with fludarabine and cyclophosphamide, patients receive a single infusion of 90110 10 CAR-positive viable T cells, delivered as a defined 1:1 ratio of CD4 and CD8 cells