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Serum bilirubin levels range from normal to 20 to 40 mg/dL, and serum albumin levels may be normal or depressed to a value as low as 1.0 to 1.5 g/dL

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Since crystallins are long-lived stable proteins with minimal turnover, accumulation of oxidative damage leads to protein cross-linking, aggregation, insolubility, and fragmentation, resulting in the formation of cataracts

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