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The lower dose (100 mg vs 500 mg in standard reduced products) reflects the theoretically higher bioavailability of the acetylated form

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As venous blood sampling is invasive, several minimally invasive microsampling methods and porous storage supports have been developed, enabling home or remote sampling as an alternative to the traditional venipuncture

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Study also foung that the oral bioavailability of monomeric bile acid is low, and the absorption and tissue distribution of bile acid in NBC is better than that in BCA (Zhao, 2007)