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Muscle Aches and Lactic Acid Buildup: Improved mitochondrial function means the body relies less on inefficient anaerobic energy production during minor exertion, which may reduce the painful buildup of lactic acid in the muscles

The production of insulin causes the body to move glucose (sugar) from the blood and into cells that use it for energy

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Heterogeneity was negligible ( I 2 =0%)

Low-dose oral folic acid treatment was sufficient to improve vascular function in patients with coronary artery disease [200]

Clarke JR, Lyra E, Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazo R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG (2015) Alzheimer-associated A oligomers impact the central nervous system to induce peripheral metabolic deregulation