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42 This is further proof that testing is important before beginning supplementation, especially with high-dose fat-soluble vitamins such as vitamin A

While the precise mechanism for the disruption of the ligand-binding interaction between these two proteins is not defined, the presence of an aggregation of GST monomers following oxidative stress implicates intermolecular disulfide bridge formation between available cysteine residues

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doi: 10.3109/01485019508987828 [DOI] [PubMed] [Google Scholar] 214