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BMJ Open 6:e012799

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Studies show that HIIT can lead to temporary spikes in GH, which may improve fat metabolism and support lean muscle development when paired with resistance training

However, megadoses might lead to acne, skin rash or interfere with certain medications

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Heterozygous mutations in and around Sox9 can lead to campomelic dysplasia, a severe form of human chondrodysplasia that affects development of the skeleton, reproductive system, and face (Foster et al., 1994