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Skin healing and anti-aging pathway models

1989;257(1 Pt 1):E65E73

reported that compared with control mice, Slc30a10 knockout mice are much smaller and have significantly higher levels of systemic Mn, and unexpectedly, Mn accumulation caused severe hypothyroidism in these mice 35 , even though the thyroid is not a primary site of Mn accumulation in human patients

Mechanisms of action of KD in neurodegeneration The classical KD is a high-fat, low-carbohydrate, and adequate-protein dietary regimen designed to mimic the metabolic effects of fasting without significant calorie restriction, thereby promoting an anabolic state [23]

Patients with underlying disorders, such as non-alcoholic fatty liver disease (NAFLD) and IBD, are more susceptible to methotrexate-induced hepatotoxicity

Beyond infertility, abrupt oestrogen deprivation accelerates osteoporosis, cardiovascular disease, mood disorders and overall biological ageing, imposing a lifelong burden on survivors [6, 7]