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As summarized, declining E2 levels during perimenopause disrupt key mitochondrial processes, such as biogenesis, antioxidant defense, calcium homeostasis, mitophagy and energy metabolism, through multiple nuclear and cytoplasmic signaling pathways (132)

By contrast, GRK2 also negatively regulates 2 -adrenergic receptor [40] and dopamine D 1 receptor (D 1 R)/adenylyl cyclase signaling [41], which should result in vasoconstriction

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On the other hand, ferroptosis inhibitors, including ferrostatin-1, iron chelators, and antioxidants, have shown potential in protecting granulosa cells from ferroptosis and oxidative damage, though clinical evidence supporting these strategies is currently lacking

Around 8% of pregnant people develop urinary tract infections (UTIs), which can cause strong-smelling urine

stanbul-Trkiye) and lead citrate (Sigma-Aldrich cat no: 15326