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1 Introduction Chronic kidney disease (CKD) represents a growing global health burden, with increasing mortality and disability-adjusted life years (DALYs) ( 2 Vitamin D metabolism and physiological functions Vitamin D is a fat-soluble prohormone that is synthesized primarily in the skin from 7-dehydrocholesterol under ultraviolet B (UVB) radiation, forming previtamin D, which is then thermally isomerized into cholecalciferol (vitamin D)

Skin quality may begin to improve with increased collagen production

Johnson 5 , (1)Department of Medicine, George Washington University Hospital, Washington, DC, (2)Alexandria University Faculty of Medicine, Alexandria, Egypt, (3)The George Washington University School of Medicine and Health Sciences, (4)George Washington University Medical Faculty Associates, (5)Department of Surgery, George Washington University Medical Faculty Associates, (6)Department of Endocrinology, George Washington University Medical Faculty Associates Background: Nonalcoholic fatty liver disease (NAFLD) is prevalent in up to 60% of patients with type 2 diabetes mellitus (T2DM)

Meaningful weight reduction (5% or more of body weight) requires 812 weeks of sustained caloric deficit alongside the injections, often with GLP-1 medication support

In response to starvation or rapamycin, ZKSCAN3 is exported to the cytoplasm, relieving repression and enabling TFEB to activate CLEAR motif-driven gene expression

This broad capacity to dampen immune activation and promote a reparative cellular environment is particularly beneficial in neuroinflammatory contexts, where chronically activated microglia and astrocytes play key roles in driving neuronal dysfunction and degeneration