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The effect of ATM-deficiency on H 2 O 2 -sensitivity was confirmed in a CII-isogenic cell line with stable knockdown of ATM ( Online Supplementary Figure S7A )

However, a cavity on the capsid surface at an inter-protomer interface, where we previously reported extra electron density 7 , has recently been identified as potentially druggable, with micro-molar binding for a benzene-sulfonamide derivative 8

For example, rectal carcinoma can be alleviated via suppressing the IKK activity

& Brinton, R

An endoperoxide reactivity-based FRET probe for ratiometric fluorescence imaging of labile iron pools in living cells

In recent years, accumulating evidence suggests that oxidative stress, mitochondrial dysfunction, and disturbances in iron homeostasis serve as upstream triggers driving these pathological cascades (Luo et al., 2019