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Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo

Finally, in gut microbiota modulation, -3 PUFAs increase the abundance of beneficial bacteria such as Bifidobacterium and Lactobacillus , and inhibit the growth of potentially harmful bacteria like Escherichia coli and Enterococcus , subsequently reducing the release of pro-inflammatory cytokines including TNF- , CRP, and IL-6, and improving systemic immune and inflammatory (168)

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10.1146/annurev-nutr-082117-051732 152 TsoiJ.RobertL.ParaisoK.GalvanC.SheuK

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After two years of treatment, an increase in bone mineral density and a decrease in urine calcium concentration was seen with both medication regimens, but the group treated with alendronate plus hydrochlorothiazide had more improvement than the group treated with alendronate alone (Arrabal-Polo, Arias-Santiago 2013)