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Diabetes (2020) 69(Suppl 1)

Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment

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GLP-1 and GIP receptor agonists have a low intrinsic risk of causing hypoglycaemia when used alone, because their insulin-stimulating effects are glucose-dependent

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The announcement was widely interpreted as a signal that the FDA under the new administration would take a more permissive stance toward peptide compounding than the 2023 Pharmacy Compounding Advisory Committee position, which had placed BPC-157 firmly in Category 2 (substances the FDA had concerns about for compounding use)