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Week 1-2 Improved sleep depth and quality

For BD patients, serum lithium concentrations must be meticulously maintained within a narrow therapeutic window, typically ranging from 0.4 to 1.0 mmol L 1 , to balance therapeutic efficacy with systemic safety

Patients undergoing combined therapy should be carefully monitored for muscle pain, tenderness, or weakness, particularly in the early months of treatment or during periods of upward dose titration of either drug

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