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However, after extensive lobbying by ALS patient advocacy groups and a promise from the company that it would consider withdrawing the drug if the larger phase 3 trial failed to confirm benefits, the advisory committee changed its mind and voted in favor of approval, Fernandez Lynch said

doi: 10.1016/j.biortech.2021.126294 230 ZhangX

Colombier et al., 2014b)

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JAMA 2011;306:1549-56

These effects on the liver and kidney probably because these organs are mainly responsible for detoxification of input compounds in the body