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LC: Conceptualization, Writing original draft, Writing review & editing

Symptoms mentioned in the reports include increased heart rate, fatigue, vomiting, loss of consciousness, and cardiac and respiratory arrest

Protects and nourishes the skin

Quercetin 3-O-(6-O-E-Caffeoyl)--D-Glucopyranoside, A flavonoid compound, promotes melanogenesis through the upregulation of mapks and akt/gsk3/-catenin signaling pathways

HIF-1 orchestrates this adaptation under low oxygen tension, transcriptionally activating glycolysis-associated genes such as glucose transporters (GLUT1/3), glycolytic enzymes (HK1/2, ENO1, PGK1, PKM2), and lactate dehydrogenase A (LDHA), thereby shifting energy production from oxidative phosphorylation to aerobic glycolysis (9496)

Objectives This review aims to elucidate the molecular and cellular mechanisms underlying PD, explore the influence of genetic and environmental factors, evaluate current treatment limitations, and assess the clinical and socioeconomic burden globally