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Group 1: normal saline (A,E,I) , group 2: hyaluronic acid (B,F,J) , group 3: AOD9604 (C,G,K) , Group 4: AOD9604 with hyaluronic acid (D,H,L) .

Jiang Z, Deaton L, Neishaboori N, Vauthey JN, Overman MJ, Maru DM, Kopetz S

Although we were successful in ectopically expressing CDO in our cell culture system, the absolute level of maximal expression for either of the CDO constructs was far less than what is normally found in vivo

Accelerated organ aging confers 2050% higher mortality risk, and organ-specific diseases relate to faster aging of those organs

10.1038/s41418-020-00685-9 16 BartzokisG.CummingsJ.PerlmanS.HanceD

Vigilant monitoring and management of these side effects are critical for therapy safety and continuity