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In vivo biological tests utilized C57BL/6 mice subjected to a subacute PD model induced by daily intravenous administration of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (40 mg/kg) for seven days

In addition, chemical treatment (such as p-nitrobenzyl chloride, iodomethane) decreases GSH content in guard cells, in turn, increases the ROS accumulation significantly and thereby enhances guard cell sensitivity to ABA signaling (Okuma et al

Stanley TL et al

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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]

Ariaeenejad, S., Hosseini, E., Motamedi, E., Moosavi-Movahedi, A