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Interestingly, CD38 does not accept either -NAD or NADH as substrates

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Put the three together and the pitch is a loop: supply NAD+, protect NAD+, then flip on the pathways that spend it productively

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selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]

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What have we, the Pernicious Anaemia Society, done

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