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Key sensors in the UPRATF6 (activating transcription factor 6), IRE1 (inositol-requiring enzyme 1 alpha), and PERK (protein kinase R-like ER kinase)are activated when misfolded protein concentrations exceed a certain threshold

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Finally, followed by sacrifice, the peripheral blood from the ophthalmic vein was collected, and submandibular gland tissues were rapidly collected for analysis