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Sleep is often disrupted by pain, and many patients have other sleep disorders, such as restless legs syndrome and sleep apnea

The complexity of the pathway can be attributed to the myriad of Wnt and Frizzled combinations as well as its diverse context-dependent functions

One miRNA in particular, the miRNA-122, was shown in a cohort who had taken APAP to significantly increase before ALT levels rose

CBS has been implicated in colorectal cancer carcinogenesis, its overexpression being detected even in precancerous lesions, such as hyperplastic polyps

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Clinically, liver injury manifests as a sharp rise in transaminases, abnormal bilirubin metabolism, and coagulation dysfunction, often combined with damage to the heart, brain, kidneys, and other organs, constituting MODS