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[2] [9] However, other research suggests that the proportion of people with low or marginal levels of vitamin B 12 is up to 40% in the Western world

421,458 Alterations in the balance of descending modulatory pathways are hypothesized to sustain chronic pain states, with a reduction in inhibitory control and an increase in facilitatory activity within both the brain and spinal cord

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The medication works through multiple complementary mechanisms