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Rare variant in metallothionein 1E increases the risk of type 2 diabetes in a Chinese population

Shammas M, Edward C, Sarkar J, et al

42:10 Dr

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

Gridelli C, Ardizzoni A, Ciardiello F, Hanna N, Heymach JV , Perrone F, Rosell R, Shepherd FA, Thatcher N, Vansteenkiste J, De Petris L, Di Maio M, De Marinis F