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When combined with Daratumumab, Panobinostat boosts antibody-dependent cellular cytotoxicity (ADCC) in both cell lines and primary MM cells

Nucleic Acids Res 32 , 143150 (2004)

We recommend calculating it based on the required dosage and the ease of measurement

Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency

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Medical Management Induction of Remission: Mild-moderate disease: Budesonide (9 mg/day) for ileocolonic disease