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Statements Author contributions Literature review was performed by AVH with assistance by DB

GHKCu (glycylLhistidylLlysine copper complex) is a naturally occurring copperbinding peptide found in human plasma, saliva, and urine that declines with age

A scheme of the experimental groups used in this study is shown in Fig S1C

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We systematically juxtapose two principal technology streams: (1) the display of protein antigens (through genetic, chemical, and bio-conjugation) and (2) the encapsulation of nucleic acid cargo (via physical, electrostatic, and programmable packaging mechanisms), evaluating each within this unified framework