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GSSG can be reversed to mGSH by glutathione reductase that requires NADPH from the pentose phosphate pathway (Baudouin-Cornu et al., 2012

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W.SudhaharV.DasA.ChandhriR.Cuervo GrajalH.et al (2018b)

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It suggests that CBS-induced GSH upregulation mitigates cisplatin toxicity through direct conjugation, instead of reducing cisplatin-induced oxidative stress

They maintain an equilibrium between astrocytic biosynthesis and oxidative degradation, which perhaps also is astrocytic and is capable of establishing net synthesis or net degradation according to glutamate needs