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Within the range of nanomolar to micromolar concentration, soluble beta-amyloid (A) oligomers impair excitatory synaptic transmission, inhibit LTP, induce loss of dendritic spines, and impair spatial memory in rodents (Crews and Masliah, 2010)

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In addition, the level of cleaved caspase-3 was significantly reduced in mice treated with BA at 40 mg/kg compared to the KA alone group (Fig