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doi: 10.1038/s41419-019-1556-7 67 VriendJReiterRJ

A meta-analysis of metabolic enzyme expression across diverse tumor types identified pyrroline-5-carboxylate reductase (PYCR1), the principal enzyme in proline biosynthesis, as one of the most commonly overexpressed genes in tumors ( in vitro results in a suppression of cell proliferation ( Serine is crucial for multiple metabolic pathways required for cell growth and proliferation, including phospholipid, purine and glutathione biosynthesis, as well as being a methyl source for single carbon metabolism

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