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The BBB is a highly selective semi-permeable barrier that exists between the CNS and blood

Brosnan MJ, Hamilton CA, Graham D, Lygate CA, Jardine E, Dominiczak AF

doi: 10.1073/pnas.0504978102 86 LiT.ChiangJ

doi:10.4103/tcmj.tcmj_255_19 [45] Agarwal A, Sengupta P, Durairajanayagam D

Moreover, lipids are digested by both host and bacterial lipases, and fatty acids can be degraded for energy release, thereby producing a long range of fatty acids (long, short, unsaturated, double bond position) which are known to be antimicrobial to many bacterial species

This method could confirm the stability of the target protein in a complex with the candidate ligands and determine the stability and rigidity of proteinligand complexes in a specific artificial environment, such as the body [32]