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Pgc1alpha activators mitigate diabetic tubulopathy by improving mitochondrial dynamics and quality control

(2022) 11:3323.10.3390/foods11213323 149

However, despite some success with agents like colchicine, the general class of broad anti-inflammatories often lacks specificity for the precise inflammatory pathways driving MIRI, leading to a poor risk-benefit profile and inconsistent efficacy in clinical trials for this acute setting