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Several prominent investigators have speculated that the pathology of this disease initiates many years prior to the emergence of clinical symptoms [32-34]

Ischemia-reperfusion injury Ischemia-reperfusion (I/R) injury is a pathological condition requiring physicians to manage local tissue damage and prevent systemic inflammation

Given the strong association with hypnotic use, consider tapering unnecessary sedatives

Iron chelators, such as deferiprone, function by binding free iron in the body, thus mitigating the oxidative stress caused by excess iron (255)

About 20% of daily fluid intake comes from food, so adding more fruits and vegetables meaningfully supports overall hydration status

Antioxidant activities Scavenging reactive oxygen and nitrogen species Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are highly reactive compounds with the potential to damage DNA, proteins, and lipids in cell membranes