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There is some research to suggest it can cause issues in people who have kidney problems

Jill 28:20 I love that

Effect and mechanism of cornus officinalis on diabetes nephropathy in rats by inhibiting oxidative stress

Sci Rep 13 , 9963 (2023)

This helps reduce bleeding risk and avoids problems with sedation or anesthesia

In addition, genetic variants in genes encoding for GPXs have been associated with increased mortality from cardiovascular diseases (Zhang et al., 2014) and diabetes (Hamanishi et al., 2004)